So your calculation is along the right lines but I think it isn’t quite right. This is because the 8.8 x 10^(-16) include the probability of failing to recombine AND transmitting a particular grandparental chromosome (a factor of 1/2 for each chromosome). So removing this, the probability of failing to recombine is 8.8 x 10^(-16)/(0.5^22)= 3.698 x10^(-9). Taking the 22 root of this (22 autosomes) gives 42% as the (geometric) mean probability of no recombination. The data underlying this is on Page 17 of this supplement (link: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000658#pgen.1000658.s001). You can divide the zero count by the sum of each row.

Thanks for you comment! ]]>

The histograms in figure 2 are hard to follow, since I don’t know what units are used for “amount transmitted”. I would naively expect the “amount transmitted” value to range from 0 (none) to 1 (all), where the 0 and 1 values mean no crossover, while values in between indicate the position of the crossover. The units you use are what? Number of base pairs?

From your data, “the probability that a male transmits every chromosome without recombination is 8.8 x 10^(-16)”, I assume I can take the 23rd root of this number, and calculate that the average probability of a chromosome being transmitted with no crossover is 22%, and thus the crossover probability of a single chromosome, on the average is 88% (for a male, and 89.5% in a female) ]]>

Looking at the graphs for 2 generations back and 4 generations back, the distributions seem to be centered on 0.5 and 0.125, respectfully. That would correspond to the distributions being centered on 1/(2^(k-1)) if I assume that “k” is the number of generations back.

Am I mistaken in how I am interpreting these graphs?

]]>That history is probably the norm, eh? Mostly farmers at the time. Living on rural farms.

]]>