Hardy-Weinberg and Ask Science

Jeremy (one of the students in the lab) acts as a moderator at the Ask Science reddit, helping answer questions on evolution, genetics, and genomics. I thought I’d post a link to a nice response of his to the question: “Why do we use the Hardy Weinberg equilibrium if it never in fact occurs in nature?”. In his response he explains how Hardy Weinberg equilibrium (HWE) is really quite a robust and useful expression. Also he links to some of the tools we’ve been developing to illustrate population genetics concepts such as HWE (see here for more).

As a quick postscript my dictation software often misinterprets the phrase “Hardy Weinberg” as “Hardly the wind blew”, which is really quite a poetic substitution.

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Population genetics notes

I’m releasing my notes on popgen here.

I’m release the pdf (and shortly the latex, figures, and code) under a creative common license in order to encourage reuse by as many folks as possible. I’ll be updating them somewhat regularly, and comments on the presentation, typos, etc are welcome here.

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Coop lab tea: Indirect Evolution of Hybrid Lethality Due to Linkage with Selected Locus in Mimulus guttatus

For Coop lab tea we’ll read:
Indirect Evolution of Hybrid Lethality Due to Linkage with Selected Locus in Mimulus guttatus
by Wright et al.

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Disentangling the effects of geographic and ecological isolation on genetic differentiation

We’ve been a bit quiet on the coop lab blog, as I’ve been devoting a bunch of my spare energy to Haldane’s Sieve, see our about page.

Gideon Bradburd, Peter Ralph, and I have just submitted our latest paper on separating the effects of geographic vs ecological adaptation on patterns of genetic differentiation. We’ve also posted the paper to the arXiv as a preprint, arXived here. Feel free to comment here or over at the abstract posted on Haldane’s sieve.

We’ll hopefully have a post up shortly about the paper.

Graham

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Distant Genetic relatives in Europe

You can read more about Peter and I’s paper [arXived here] in the guest post we wrote over at Haldane’s Sieve. There’s a nice discussion on some of the technical details in the comments there.

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Journal tea: Oct 23rd Distinguishing between Selective Sweeps from Standing Variation and from a De Novo Mutation

Distinguishing between Selective Sweeps from Standing Variation and from a De Novo Mutation Peter et al

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Journal tea: Sept 5th Turchin et al

Evidence of widespread selection on standing variation in Europe at height-associated SNPs Turchin et al.

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Journal tea: Aug 29th

Demographic Inference Using Spectral Methods on SNP Data, With an Analysis of the Human out-of-Africa Expansion.

Lukic S, Hey J. Genetics 2012

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Journal tea

For wednesday we’ll read Skoglund et al Science 2012

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journal tea

This week we’ll read Common SNPs explain a large proportion of the heritability for human height by Yang et al.

see also this commentary by Visscher’s groups.

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