Slides of Coop Lab talks/posters at SMBE

Slides from the Coop lab talks are posted below. Note that much of this work is ongoing, so please treat it as provisional. Contact us if you’d like to know more, or if you want to build on it.

Alisa Sedghifar. The Spatial Mixing of Genomes in Secondary Contact Zones

Kristin Lee. Distinguishing modes of convergent adaptation in genomic data

Chenling Xu. A novel fine-scale human recombination map reveals sex differences

Gideon Bradburd. Inferring population structure across space and time

Simon Aeschbacher. Robust inference of selection against maladaptive gene flow

Ivan Juric Quantifying selection against Neanderthal introgression

Jeremy Berg. Patterns of Genetic and Haplotypic Variation surrounding a Sweep from Standing Variation. We’ll post this shortly.
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illustrations of lab SMBE talks by Alex Cagan

One of the best features of conference coverage of SMBE has been Alex Cagan’s illustrations of talks. A few folks in the lab were luckily enough to be in the sessions that Alex was drawing in; his illustrations of their talks are below. Thanks to Alex for these wonderful pictures!

Kristin_SMBE15_Alex_Caganlink to original.

Gideon_SMBE15_Alex_Cagan
link to original.

Simon_SMBE15_Alex_Cagan
link to original.

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Does grasshopper sperm evolve to make female meiosis fair?

Juan Pedro M. Camacho alerted Yaniv and myself towards Herrera et al. 1996 –a potential example of male control of female meiotic drive being exposed in crosses among grasshopper populations– as we predicted in our paper (Brandvain and Coop, “Sperm should evolve to make female meiosis fair” ). It’s a shame that we missed citing this in our paper, but it’s great to see an example of one of our predictions potentially being correct. We’ve posted the comment pasted below at pubmed commons.

After our paper appeared we were made aware of a great potential example of paternal control of female meiotic transmission (Herrera et al. 1996). In many species dispensable supernumerary B-chromosomes are preferentially transmitted to offspring, with this preferential segregation (drive) often occurring through female meiosis (Jones 1991, Burt and Trivers 2006). Herrera et al. studied a widespread B chromosome polymorphism in the grasshopper, Eyprepocnemis plorans. In crosses between 1B females and males from the same focal population in which B-chromosomes were present, B-chromosomes were transmitted following Mendelian ratios. However, when the same females were crossed to males from a population where the B chromosome was not present, they transmitted their B-chromosome to much more than half of their progeny. There was no obvious reduction in fertility, suggesting that this was not due to lethality and potentially due to meiotic drive. Herrera et al suggested that the male control of female meiosis is exerted during the first meiotic division, perhaps due to an effect of substances in the male ejaculate. These results are consistent with our hypothesis that sperm-based suppressors of drive may arise and spread in response to the spread of female meiotic drive elements (such as B-chromosomes), such that female meiotic drive can re-emerge when eggs are exposed to specific sperm from a population where drive suppression had not evolved. We thank Juan Pedro M. Camacho (Universidad de Granada) for kindly bringing this example to our attention and for feedback on this note.

Yaniv Brandvain and Graham Coop

Cited References:

Jones, R.N. 1991. B-Chromosome Drive. American Naturalist 137: 430-442.

Burt, A. and R. Trivers, 2006. Genes in conflict. Belknap Press, Cambridge.

Herrera, J. A., M. D. López-León, J. Cabrero, M. W. Shaw and J. P. M. Camacho. 1996. Evidence for B chromosome drive suppression in the grasshopper Eyprepocnemis plorans. Heredity 76: 633–639.

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Coopons at SMBE

The Coop lab are looking forward to SMBE in Vienna next week. We’ve listed our talks below.

Jeremy Berg. Patterns of Genetic and Haplotypic Variation surrounding a Sweep from Standing Variation
130B Poster session A Mon 13-Thurs16

Alisa Sedghifar. The Spatial Mixing of Genomes in Secondary Contact Zones
34B Poster session B Mon 13-Thurs16

Kristin Lee. Distinguishing modes of convergent adaptation in genomic data
10AM Population Genomics of Rapid Adaptation. Tues July 14 Festsaal

Chenling Xu. A novel fine-scale human recombination map reveals sex differences
12:15 PM Genomics of sex bias. Wed, July 15 Forum

Gideon Bradburd. Inferring population structure across space and time
10 AM Fitch Symposium Wed, July 15 Festsaal

Simon Aeschbacher. Robust inference of selection against maladaptive gene flow
16:45 PM demography vs. selection debate Wed July 15 Forum

Ivan Juric Quantifying selection against Neanderthal introgression
9:30 AM Ancient Genomes Thr July 16 Prinz Eugen

Keep an eye out for our new Coop lab t-shirts

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Gideon’s exit seminar & FroYo in Space

A few pictures from Gideon’s exit seminar celebrations.

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Chenling, Helena, Marge, Gideon, Jeremy, Kristin, Graham, Vince, Alisa, Ivan, & Simon.
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Gid’s exit seminar was great. A bunch of Gid’s friends and family contributed good luck messages including Luke, Peter, & Yaniv:
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The second year CPB students made a “FroYo in space” ice cream bar, with homemade frozen yoghurt & toppings, to accompany Gid’s seminar
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We’re not sure if Gid was more excited by his exit seminar or the frozen yoghurt to be honest:
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Coop Lab BBQ/BBCoop

Gid and Marge kindly hosted a BBQ at their place for the Coop Lab.
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Front row: Kristin, Chenling, Alisa, Graham.
Back row: Gideon, Ivan, Jeremy, Vince, Simon.

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Much violence was done to wooden blocks. Vince taught us how to play Kubb:
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And we played Jenga, note the strict safety-first policy of the Coop lab ;)

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Coop Lab BBQ (BBCoop?)

Random BBQ/taco night to celebrate the end of the quarter. We forgot to take any pictures until after we moved inside, so we are missing some folks. A great time, and much grilled meat and veggies, were had by all!

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[Kristin, Vince, Gideon, Graham and Alisa enjoying some fine port (note the fancy port sippers modeled by all but Graham)]

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[Ivan, Vince, Marge, Kristin, & Alisa (Simon in background)]

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[Simon, Kristin, Vince, & Helene]

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