Jeremy’s exit seminar & outstanding dissertation prize

Congratulations to Jeremy Berg on his exit seminar & on winning the UCDavis Merton Love Evolution and Ecology outstanding dissertation prize. Jeremy gave a great seminar on his dissertation work on soft sweeps and polygenic adaptation on human height.


The lab made cookies showing human height variation


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Nancy’s biology of genomes talk

Nancy presented her work on the genomics of short-term selection in the Florida Scrub Jays  at the CSHL Biology of genomes meeting. You can read a writeup of the work here.

Nancy’s talk was wonderfully illustrated by Alex Cagan:


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what is genetic correlation?

With the availability of genomic data on large cohorts of well-phenotyped individuals, there has been an increased interest in “genetic correlations” between traits. That is, when testing a set of genetic variants for association with two traits, are the effects of these genetic variants on the two traits correlated?

These are now simple, easy-to-use software packages for calculating these genetic correlations (e.g.), and it is clear that many traits show some evidence for genetic correlation. For example, LDL cholesterol and risk of coronary artery disease are genetically correlated (e.g.).

The most obvious interpretation of a genetic correlation is that it arises as a result of pleiotropy [1]–alleles that affect one trait on average also have an affect on a second trait.
This intepretation can shed powerful light on the shared genetic basis of phenotypes, and can also allow the dissection of casual relationships among phenotypes (through approaches such as Mendelian randomization).

Increasingly, however, we will be faced with genetic correlations that are complex to understand and may have multiple casual underpinnings: for example, height is genetically correlated to socioecomonic status, and educational attainment is negatively genetically correlated to body mass index.

Often when these genetic correlations are described they are simply referred to as
correlations; this avoids the issue of specifying how they arise. In some cases, though, genetic correlations are directly referred to as pleiotropy. However, quantative geneticists have known for a long time that genetic correlations arise for a variety of related reasons (e.g.). It is tempting to see the genetic correlations found by GWAS approaches as side-stepping these long-discussed issues. Indeed, if done well they can indeed bypass some concerns (e.g. that correlations between phenotypes within families could be driven a shared environment). However, the deeper issue that genetic correlations can arise through multiple mechanisms has not gone away.

In this post, we want to discuss some of the possible interpretations of a genetic correlation. We start with the two most common interpretations (putting aside analysis artifacts like shared population statification), and then discuss two additional possibilities, rarely directly tested, that merit further investigation.

1. “Biological” pleiotropy. In this situation, genetic variants that influence one trait also influence another because of some shared underlying biology. For example, genetic variants that influence age at menarche in women have correlated effects on male pattern baldness. Presumably this is because there are some shared hormonal pathways that influence both of these traits, such that altering these pathways has effects on multiple traits.


2. “Mediated” pleiotropy. In this situation, one trait is directly causally influenced by another. This of course means that a genetic variant that influences the first phenotype will have knock-on effects on the second. The classic example here is LDL cholesterol and heart disease: these two traits are positively genetically correlated, and it is now widely accepted that this correlation is due to a causal effect of LDL on risk of developing disease. Identifying this situation is has important medical implications: since LDL is causal for heart disease, then a non-genetic intervention that influences LDL (for example, a drug or an altered diet) should have an effect on someone’s risk of heart disease.


We note that both forms of pleiotropy may be environmental or culturally mediated. For example, if shorter people are discriminated against in the job market this would generate a genetic correlation between height and socioecomonic status that fits a model of “mediated” pleiotropy.

These two explanations of a genetic correlation are of course plausible. Some other models also seem quite plausible; the relative importance of these different models remains to be seen.

3. Parental effects. For example, imagine that more educated parents pay more attention to the diets of their children, and thus their children have lower rates of obesity. This would be detected in GWAS as a genetic correlation between educational attainment and obesity, though the causal connection between the variant and the two traits is
less direct than in the previous two situations. Parental effects can be termed pleiotropy, but importantly the effect is due to the parental genotype, and not that of the child, and so it can be distinguished from within-generation pleiotropy (see below).


4. Assortative mating. For example, imagine taller individuals tend to marry individuals with higher socioecomonic status. This would induce a genetic correlation between the traits. What is happening is that the alleles that associated with both traits co-occur in the same individuals (the offspring of these assortatively-mating


To illustrate this point, we simulated two traits that share no pleiotropic genetic variants in common with 100 unlinked loci each. We simulated cross-trait positive assortative mating for a single generation [2]. We then plotted the effect sizes of the variants casually affecting trait 1 against these perceived affect of these loci on trait 2, as estimated from a sample of 100k children. There is a clear relationship induced by even a single generation of assortative mating.

When alleles that increase both traits are brought together in the offspring this induces a form of linkage disequibrium (LD) between the loci underlying the same traits (even if the loci are not genetically linked). If this assortative mating continues over multiple generations this LD effect is compounded and builds to an equilibrium level of
genetic correlation between the two traits (Gianola 1982).


How can we determine the relative contributions of these latter two causes of genetic correlation?
Family studies could help–for example, studies in the UK Biobank have shown that assorative mating contributed to the heritability of height [3], this style of study could be extended to cross-trait comparisons. For example, the polygenic score for each phenotype could be calculated for each parent, and the genetic correlation between parents could be
estimated.This would allow for the genetic effect of assortative mating to the assessed. Although we note that even if assortative mating is absent in the parental generation, genetic correlations from previous generations of assortative mating could be present (as
they decay through meiotic segregation and recombination).

Similarly, parental effects can be tested by estimating polygenic scores for parent and child (see e.g. Zhanget al.); the contribution of parental and child’s genotype can then
be assessed.

Overall, the study of genetic correlations using GWAS data has opened up a number of interesting directions for future work; new methods and analyses are needed to distinguish among these various causes of genetic correlation (and of course, others we have not discussed here).

Joe Pickrell & Graham Coop

[1] Note that the pleiotropy we see as quantitative geneticists can be mediated through environmental effects. This is simply a statement that alleles affect multiple traits, not that those shared effects have simple “molecular” basis.

[2] Details of the simulation: we simulated 100 genetic variants influencing a trait with 50% narrow-sense heritability. Effect sizes for each locus affecting trait 1 were drawn from a normal distribution, with no effect on trait 2 and the same for the loci affecting trait two.
We simulated positive assortative mating with a given correlation coefficient (0.3 in this case) by simulating a male’s phenotype (trait 2)given the female phenotype (trait 1) from the conditional normal, then choosing the male who’s value of trait 2 was closest to this.
The complete simulation code is available here.

[3] Indeed, while we have explained all of these effects in terms of genetic covariance, they can also contribute to inflating the additive genetic variance contributed by a trait. For example, couples assortatively mate by height, therefore, alleles contributing to tallness tend to be present in taller individuals even more than we would predict from their
‘true’ effect size. Therefore, the effect sizes of alleles may be
mildly overestimated by this effect.


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Coopon Brunch

Coopon_brunch_2.jpgAnita To, Jeremy Berg, Graham, Nancy Chen, Emily Josephs, Vince Buffalo, Kristin Lee, Simon Aeschbacher.

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Slides of Coop Lab talks/posters at SMBE

Slides from the Coop lab talks are posted below. Note that much of this work is ongoing, so please treat it as provisional. Contact us if you’d like to know more, or if you want to build on it.

Alisa Sedghifar. The Spatial Mixing of Genomes in Secondary Contact Zones

Kristin Lee. Distinguishing modes of convergent adaptation in genomic data

Chenling Xu. A novel fine-scale human recombination map reveals sex differences

Gideon Bradburd. Inferring population structure across space and time

Simon Aeschbacher. Robust inference of selection against maladaptive gene flow

Ivan Juric Quantifying selection against Neanderthal introgression

Jeremy Berg. Patterns of Genetic and Haplotypic Variation surrounding a Sweep from Standing Variation. We’ll post this shortly.

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illustrations of lab SMBE talks by Alex Cagan

One of the best features of conference coverage of SMBE has been Alex Cagan’s illustrations of talks. A few folks in the lab were luckily enough to be in the sessions that Alex was drawing in; his illustrations of their talks are below. Thanks to Alex for these wonderful pictures!

Kristin_SMBE15_Alex_Caganlink to original.

link to original.

link to original.

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Does grasshopper sperm evolve to make female meiosis fair?

Juan Pedro M. Camacho alerted Yaniv and myself towards Herrera et al. 1996 –a potential example of male control of female meiotic drive being exposed in crosses among grasshopper populations– as we predicted in our paper (Brandvain and Coop, “Sperm should evolve to make female meiosis fair” ). It’s a shame that we missed citing this in our paper, but it’s great to see an example of one of our predictions potentially being correct. We’ve posted the comment pasted below at pubmed commons.

After our paper appeared we were made aware of a great potential example of paternal control of female meiotic transmission (Herrera et al. 1996). In many species dispensable supernumerary B-chromosomes are preferentially transmitted to offspring, with this preferential segregation (drive) often occurring through female meiosis (Jones 1991, Burt and Trivers 2006). Herrera et al. studied a widespread B chromosome polymorphism in the grasshopper, Eyprepocnemis plorans. In crosses between 1B females and males from the same focal population in which B-chromosomes were present, B-chromosomes were transmitted following Mendelian ratios. However, when the same females were crossed to males from a population where the B chromosome was not present, they transmitted their B-chromosome to much more than half of their progeny. There was no obvious reduction in fertility, suggesting that this was not due to lethality and potentially due to meiotic drive. Herrera et al suggested that the male control of female meiosis is exerted during the first meiotic division, perhaps due to an effect of substances in the male ejaculate. These results are consistent with our hypothesis that sperm-based suppressors of drive may arise and spread in response to the spread of female meiotic drive elements (such as B-chromosomes), such that female meiotic drive can re-emerge when eggs are exposed to specific sperm from a population where drive suppression had not evolved. We thank Juan Pedro M. Camacho (Universidad de Granada) for kindly bringing this example to our attention and for feedback on this note.

Yaniv Brandvain and Graham Coop

Cited References:

Jones, R.N. 1991. B-Chromosome Drive. American Naturalist 137: 430-442.

Burt, A. and R. Trivers, 2006. Genes in conflict. Belknap Press, Cambridge.

Herrera, J. A., M. D. López-León, J. Cabrero, M. W. Shaw and J. P. M. Camacho. 1996. Evidence for B chromosome drive suppression in the grasshopper Eyprepocnemis plorans. Heredity 76: 633–639.

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Coopons at SMBE

The Coop lab are looking forward to SMBE in Vienna next week. We’ve listed our talks below.

Jeremy Berg. Patterns of Genetic and Haplotypic Variation surrounding a Sweep from Standing Variation
130B Poster session A Mon 13-Thurs16

Alisa Sedghifar. The Spatial Mixing of Genomes in Secondary Contact Zones
34B Poster session B Mon 13-Thurs16

Kristin Lee. Distinguishing modes of convergent adaptation in genomic data
10AM Population Genomics of Rapid Adaptation. Tues July 14 Festsaal

Chenling Xu. A novel fine-scale human recombination map reveals sex differences
12:15 PM Genomics of sex bias. Wed, July 15 Forum

Gideon Bradburd. Inferring population structure across space and time
10 AM Fitch Symposium Wed, July 15 Festsaal

Simon Aeschbacher. Robust inference of selection against maladaptive gene flow
16:45 PM demography vs. selection debate Wed July 15 Forum

Ivan Juric Quantifying selection against Neanderthal introgression
9:30 AM Ancient Genomes Thr July 16 Prinz Eugen

Keep an eye out for our new Coop lab t-shirts


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Gideon’s exit seminar & FroYo in Space

A few pictures from Gideon’s exit seminar celebrations.

Chenling, Helena, Marge, Gideon, Jeremy, Kristin, Graham, Vince, Alisa, Ivan, & Simon.
Gid’s exit seminar was great. A bunch of Gid’s friends and family contributed good luck messages including Luke, Peter, & Yaniv:
The second year CPB students made a “FroYo in space” ice cream bar, with homemade frozen yoghurt & toppings, to accompany Gid’s seminar
We’re not sure if Gid was more excited by his exit seminar or the frozen yoghurt to be honest:

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Coop Lab BBQ/BBCoop

Gid and Marge kindly hosted a BBQ at their place for the Coop Lab.
Front row: Kristin, Chenling, Alisa, Graham.
Back row: Gideon, Ivan, Jeremy, Vince, Simon.


Much violence was done to wooden blocks. Vince taught us how to play Kubb:

And we played Jenga, note the strict safety-first policy of the Coop lab 😉

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