In my last couple of posts I talked about how much of your (autosomal) genome you inherit from a particular ancestor [1,2]. In the chart below I show a family tree radiating out from one individual. Each successive layer out shows an individual’s ancestors another generation back in time, parents, grandparents, great-grandparents and so on back (red for female, blue for male).

Each generation back your number of ancestors double, until you are descended from so many people (e.g. 20 generation back you potentially have 1 million ancestor) that it is

quite likely that some people back then are your ancestors multiple times over. How quickly then does your number of genetic ancestors grow, i.e. those ancestors who contributed genetic material to you?

Each generation we go back is expected to halve the amount of autosomal genetic material an ancestor gives to you. As this material inherited in chunks, we only have to go back ~9 generations until it is quite likely that a specific ancestor contributed zero of your autosomal material to you (see previous post). This process is inherently random, as the process of recombination (the breaking of chromosomes into chunks) and transmission are both random sets of events. To give more intuition, and to demonstrate the nature of the randomness, I thought I’d setup some simulations of the inheritance genetic process back through time.

Below I show the same plot as above (going back 11 generations), but now ancestors that contribute no (autosomal) chunks of genetic material are coloured white (I give the % of ancestors with zero contribution below). I also wanted to illustrate how variable the contribution of (autosomal) genetic material was across ancestors in a particular generation. So I altered the shade of the colour of the ancestor to show what fraction of the genome they contributed. In choosing a scale I divided that fraction through by the maximum contribution of any ancestor in that generation, so that the individual who contributed the most is the darkest shade. Below the figure I give the range of % contributions to this individual, and the mean (which follows 0.5^{k}).

It’s quite fun to trace particular branches back and see their contribution change over time. These figures were inspired by ones I found at the genetic genealogy blog. I’m not sure how they generated them, and they are for illustrative purposes only. I made scripts to do the simulations and plot in R. I’ll post these scripts to github shortly.

To give a sense of how variable this process is, here’s another example

From these it is clear that your number of ancestors is increasing but no where near as fast as your number of genealogical ancestors. To illustrate this I derived a simple approximation to the number of genetic ancestors over the generations (I give details below). Using this approximation I derived the number of genetic and genealogical ancestors, in a particular generation, going back over 20 generations:

Your number of genealogical ancestors, in generation k, is growing exponentially (I cropped the figure as otherwise it looks silly). Your number of genetic ancestors at first grows as quickly as your number of genealogical ancestors, as it is very likely that an ancestor a few generations back is also a genetic ancestor. After a few more generations your genetic number of genetic ancestors begins to slow down its rate of growth, as while the number of genealogical ancestors is growing rapidly fewer and fewer of them are genetic ancestors. Your number of genetic ancestors eventually settles down to growing linearly back over the generations, at least over the time-scale here, with your number of ancestors in generation k being roughly 2*(22+33*(k-1)).

To get at this result I did some approximate calculations. If we go back k generations, the autosomes you received from (say) your mum are expected to be broken up in to roughly (22+33*(k-1)) different chunks spread across ancestors in generation k (you have 22 autosomes, with roughly 33 recombination events per generation). If we go far enough back each ancestor is expected to contribute at most 1 block, so you have roughly 2*(22+33*(k-1)) (from your mum and dad).

To develop this a little more consider the fact that k generations back you have 2 ^{(k-1)} ancestors k generations back on (say) your mother’s side, you expect to inherit (22+33*(k-1))/2^{(k-1)} chunks from each ancestor. We can approximate the distribution of the number of chunks you inherit from a particular ancestor by a Poisson distribution with this mean*. So the probability that you inherit zero of your autosomal genome from a particular ancestor is approximately exp(-(22+33*(k-1))/2 ^{(k-1)}). This approximation seems to work quite well, and matches my simulations:

So using this we can write your expected number of genetic ancestors as 2^{k} *(1- exp(-(22+33*(k-1))/2^{(k-1)})), as you have 2^{k} ancestors each contribute genetic material to you with probability one minus the probability we just derived. When we go back far enough exp(-(22+33*(k-1))/2^{(k-1)}) ≈ 1- (22+33*(k-1))/2^{(k-1)}, so your number of ancestors, in generation k, is growing linearly as 2*(22+33*(k-1)).

Your number of genetic ancestors will not grow linearly forever. If we go far enough back your number of genetic ancestors will get large enough, on order of the size of the population you are descended from, that it will stop growing as you will be inheriting different chunks of genetic material from the same set of individuals multiple times over. At this point your number of ancestors will begin to plateau. Indeed, once we go back far enough actually your number of genetic ancestors will begin to contract as human populations have grown rapidly over time. I’ll return to this in another post.

* this will be okay if k is sufficiently large, I can explain this in the comments if folks like. This approximation has been made by many folks, e.g. Huff *et al.* in estimating genetic relationships between individuals.

This post was inspired in part by an nice post by Luke Jostins (back in 2009). I think there were some errors in Luke’s code. I’ve talked this over with Luke, and he’s attached a note to the old post pointing folks here.

This is interesting but kind of self evident. I’d be interested in answering another question which you can perhaps derive from your analysis. Given that two people are, let’s say, fourth cousins, what is the distribution function of the amount of autosomal DNA they share? What is the probability that they share a certain amount (in terms of cM)? What is the probability that they share zero?

You can read about calculations of how much of the genome cousins share here. One of the reasons for doing this first round of calculations is to give people intuition so that I can do the calculations of how much relatives will share in a subsequent post.

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A related question is one’s Maternal / Paternal Lineage Extinction Ratio (MLER/PLER); a parameter that may help explain speciation and what appears to be population bottlenecking. Look up ‘Inevitable Eve’.

These ideas are at the heart of coalescent theory, which describes the genealogy of individual genetic loci in the genome. The history of maternal and paternal markers (mtDNA and Y chromosome) are just two examples of this phenomenon. I’m hoping to write up more on these connections in the near future.

If you would like to print these charts with your own family data, check out:

http://progenygenealogy.com/products/family-tree-charts.aspx

(Both Ancestor and Descendant Fan charts)

I tried doing this same computation at http://burtleburtle.net/bob/future/ancestors.html , and it produced similar results. Except I’m getting about 84 additional ancestors per generation instead of 66. I had the computation measure how many ancestors contributed 1/2^^n of the total DNA as well.

Ah-hah, I was testing (i < crossovers) where crossovers was a double rather than int, so I got one more crossover per chromosome per generation. Will fix that.

Are you simulating the X as well?

Yes, I’m handling X and Y specially. X has crossovers in females, but not in males. Even in females you get one or two strongly related ancestors quite back due to X recombining only every other generation. I had a bug for awhile where one of the X from daughter was interpreted by the father as Y, but I fixed that. (The male contribution to the daughter is actually the female contribution to the father.) Currently I’m getting an additional 68 ancestors per generation.

So I’m not doing the X chromosome, but I’m planning to add it in shortly. I need to work on the visualization to handle doing it.

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